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Moving rehabilitation research forward: developing consensus statements for rehabilitation and recovery research

机译:推进康复研究:为康复和康复研究制定共识声明

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摘要

Stroke recovery is the next frontier in stroke medicine. While growth in rehabilitation and recovery research is exponential, a number of barriers hamper our ability to rapidly progress the field. Standardized terminology is absent in both animal and human research, methods are poorly described, recovery biomarkers are not well defined, and we lack consistent timeframes or measures to examine outcomes. Agreed methods and conventions for developing, monitoring, evaluating and reporting interventions directed at improving recovery are lacking, and current approaches are often not underpinned by biology. We urgently need to better understand the biology of recovery and its time course in both animals and humans to translate evidence from basic science into clinical trials. A new international partnership of stroke recovery and rehabilitation experts has committed to advancing the research agenda. In May 2016, the first Stroke Recovery and Rehabilitation Roundtable will be held, with the aim of achieving an agreed approach to the development, conduct and reporting of research. A range of methods will be used to achieve consensus in four priority areas: pre-clinical recovery research; biomarkers of recovery; intervention development, monitoring and reporting; and measurement in clinical trials. We hope to foster a global network of researchers committed to advancing this exciting field. Recovery from stroke is challenging for many survivors. They deserve effective treatments underpinned by our evolving understanding of brain recovery and human behaviour. Working together, we can develop game-changing interventions to improve recovery and quality of life in those living with stroke.
机译:中风恢复是中风医学的下一个前沿领域。尽管康复和恢复研究的发展呈指数级增长,但许多障碍阻碍了我们快速发展该领域的能力。动物和人类研究均缺乏标准化的术语,方法描述不清,回收生物标记物定义不清,我们缺乏一致的时间表或检查结果的措施。缺乏用于开发,监测,评估和报告旨在改善康复的干预措施的商定方法和惯例,而当前的方法通常不受生物学支持。我们迫切需要更好地了解动物和人类的恢复生物学及其恢复过程,以便将基础科学的证据转化为临床试验。由中风康复专家组成的新的国际伙伴关系致力于推进研究议程。 2016年5月,将举行首届卒中恢复和康复圆桌会议,以期就研究的开发,进行和报告达成共识。一系列方法将用于在四个优先领域达成共识:临床前恢复研究;恢复的生物标志物;干预措施的开发,监测和报告;和临床试验中的测量。我们希望建立致力于致力于发展这一激动人心领域的全球研究人员网络。对于许多幸存者来说,从中风中恢复是具有挑战性的。在我们对脑恢复和人类行为不断发展的了解的基础上,他们应该得到有效的治疗。通过共同努力,我们可以开发出改变游戏规则的干预措施,以改善中风患者的康复和生活质量。

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